Description

4-Chloroestradiol is a halogenated derivative of the natural hormone estradiol, distinguished by the substitution of a chlorine atom at the 4-position of the aromatic A-ring. This structural modification significantly alters its biological activity and metabolic profile, making it a compound of high interest in advanced research and development. It serves as a critical intermediate and reference standard in the synthesis of novel steroidal compounds and in pharmacological studies. This product is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors focused on endocrinology, oncology, and steroid chemistry.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel steroidal drugs and therapeutic agents targeting hormone receptors.
• Biochemical Research: Used as a reference standard and probe compound in studies of estrogen receptor (ER) binding affinity, selectivity, and downstream signaling pathways.
• Metabolic Studies: Investigation of the metabolic fate, stability, and transformation pathways of halogenated steroids in biological systems.
• Academic & Institutional Research: A vital tool for universities and research institutes conducting fundamental studies in endocrinology, oncology, and chemical biology.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for method development and quality control in analytical laboratories (HPLC, GC-MS, LC-MS).
• Preclinical Development: Evaluation of pharmacokinetic and pharmacodynamic properties in animal models for potential therapeutic applications.

Basic Information

Product Name	4-Chloroestradiol
CAS No.	88847-88-5
Molecular Formula	C18H23ClO2
Molecular Weight	306.83 g/mol
Synonyms	4-Chloroestra-1,3,5(10)-triene-3,17β-diol; 4-Chloro-17β-estradiol; 4-Chloro-E2; 4-Cl-Estradiol; 4-Chloro-1,3,5(10)-estratriene-3,17β-diol; 4-Chloro-17β-hydroxyestra-1,3,5(10)-trien-3-ol; Estra-1,3,5(10)-triene-3,17β-diol, 4-chloro-
EINECS	Contact for details

Quality Control

Our 4-Chloroestradiol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, identification by spectroscopic methods (IR, NMR), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.