Description

(+)-Xestospongin A CAS NO 88840-02-2 is a high-purity, naturally derived alkaloid isolated from marine sponges, recognized as a potent and selective inhibitor of the inositol 1,4,5-trisphosphate (IP3) receptor. This compound is a critical research tool for investigating intracellular calcium signaling pathways, which are fundamental to numerous physiological and pathological processes. It is essential for researchers and developers in pharmacology, neuroscience, and cell biology who require reliable, high-quality biochemical tools for target validation and mechanistic studies.

Application

• Biochemical Research: As a selective IP3 receptor antagonist to study calcium (Ca²⁺) release from endoplasmic reticulum stores in cellular models.
• Neuroscience Studies: For investigating the role of IP3-mediated signaling in neuronal function, synaptic plasticity, and neurodegenerative disease mechanisms.
• Cardiovascular Research: Used to elucidate IP3 receptor involvement in cardiac muscle contraction and vascular smooth muscle cell signaling.
• Pharmacological Screening: Serves as a reference standard and tool compound in high-throughput screening assays for drug discovery targeting calcium signaling.
• Cell Biology: Employed to probe apoptosis, cell proliferation, and other cellular processes regulated by intracellular calcium dynamics.
• Academic & Institutional Research: A key reagent for basic scientific research in university and government laboratories worldwide.

Basic Information

Product Name	(+)-Xestospongin A
CAS No.	88840-02-2
Molecular Formula	C₂₂H₂₂N₂O₄
Molecular Weight	378.42 g/mol
Synonyms	Xestospongin A; (7R,7aS,14aR)-7-Methyl-5,6,7,7a,8,13,14,14a-octahydro-2H,12H-[1,3]dioxolo[4,5-g]pyrido[1',2':1,2]azepino[4,5-b]indol-12-one; IP3 Receptor Inhibitor I; IP3R Inhibitor
EINECS	Contact for details

Quality Control

Our (+)-Xestospongin A is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized using advanced analytical techniques, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profile is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.