Description

Xestospongine B is a bioactive marine alkaloid isolated from sponges of the genus *Xestospongia*. This compound is of significant interest for its potent and selective activity as an inhibitor of the inositol 1,4,5-trisphosphate (IP3) receptor, a key regulator of intracellular calcium signaling. It serves as a critical research tool for neuroscientists, pharmacologists, and cell biologists investigating calcium-dependent processes, neuronal signaling, and potential therapeutic pathways. Global demand is driven by academic research institutions, pharmaceutical R&D departments, and biotechnology companies focused on neurological and cardiovascular drug discovery.

Application

• Neuroscience Research: As a selective IP3 receptor antagonist, it is used to study calcium signaling in neurons, synaptic plasticity, and neuronal cell death mechanisms.
• Cardiovascular Research: Employed in investigations of IP3-mediated calcium release in cardiac myocytes and vascular smooth muscle cells.
• Cell Biology Studies: A vital tool for probing the role of intracellular calcium stores in apoptosis, cell proliferation, and gene expression.
• Pharmacological Screening: Used as a reference standard and active agent in high-throughput screens for novel modulators of calcium signaling pathways.
• Biochemical Assay Development: Serves as a key component in developing and validating assays targeting the IP3 receptor complex.
• Drug Discovery & Development: Provides a structural and functional template for designing new therapeutic agents targeting calcium dysregulation diseases.

Basic Information

Product Name	Xestospongine B
CAS No.	88840-01-1
Molecular Formula	C₂₂H₂₈N₂O₄
Molecular Weight	384.47 g/mol
Synonyms	Xestospongin B; IP3 Receptor Antagonist; 1H-Pyrrolo[2,3-g]isoquinoline-5-carboxamide, 1,2,3,4,6,7,12,12b-octahydro-2-methyl-; (7R,12bS)-2-Methyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-7-ol; Marine Alkaloid Xestospongin B
EINECS	Contact for details

Quality Control

Our Xestospongine B is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, potency, and analytical results is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; desiccants are recommended for long-term storage. Keep container tightly sealed under an inert atmosphere when specified.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, Methanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.