Description

(3R)-3,4-Dihydro-7-Methylbenzo[A]Anthracene-3β,4α-Diol CAS NO 88244-38-6 is a high-purity, stereospecific dihydrodiol derivative of a methyl-substituted benzo[a]anthracene. This compound is a critical advanced intermediate and reference standard in biochemical and toxicological research, particularly for studying polycyclic aromatic hydrocarbon (PAH) metabolism and DNA adduct formation. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and analytical testing facilities engaged in carcinogenesis studies and metabolic pathway analysis.

Application

• Biochemical Research Intermediate: Serves as a key precursor or metabolite analog in the study of polycyclic aromatic hydrocarbon (PAH) activation and detoxification pathways.
• Toxicology and Carcinogenesis Studies: Used as a reference compound to investigate the mechanisms of DNA damage, mutagenicity, and tumor initiation caused by specific PAH derivatives.
• Analytical Reference Standard: Employed in high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), and other analytical methods for the identification and quantification of PAH metabolites in complex matrices.
• Enzymology Studies: Acts as a substrate or inhibitor in assays for cytochrome P450 enzymes and epoxide hydrolases to elucidate enzyme specificity and kinetics.
• Pharmaceutical Development: Potential use in the synthesis of specialized compounds for probing biological targets related to chemical toxicity.

Basic Information

Product Name	(3R)-3,4-Dihydro-7-Methylbenzo[A]Anthracene-3β,4α-Diol
CAS No.	88244-38-6
Molecular Formula	C19H16O2
Molecular Weight	276.33 g/mol
Synonyms	(3R,4S)-3,4-Dihydro-7-Methylbenzo[a]anthracene-3,4-diol; 7-Methylbenz[a]anthracene (3R,4S)-dihydrodiol; (3R,4S)-7-Methylbenz[a]anthracene-3,4-diol; 7-Methyl-BA-dihydrodiol; 7-Methylbenz[a]anthracene trans-3,4-dihydrodiol; trans-3,4-Dihydroxy-3,4-dihydro-7-methylbenz[a]anthracene; 7-Methyl-BA-3,4-diol
EINECS	Contact for details

Quality Control

Our (3R)-3,4-Dihydro-7-Methylbenzo[A]Anthracene-3β,4α-Diol is manufactured under controlled conditions to ensure high stereochemical purity and batch-to-batch consistency, critical for research reproducibility. Each lot undergoes rigorous analytical characterization, including chiral HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The compound is light-sensitive and should be handled under subdued lighting. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (3R,4S)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.