Description

(4R,5E,7Z,12S,14Z)-4,12,20-Tris(Acetyloxy)-9-Oxo-5,7,10,14-Prostatetren-1-Oic Acid Methyl Ester is a high-purity, synthetic prostaglandin analog and a key advanced intermediate in pharmaceutical research and development. This compound is critical for its role in the synthesis of complex bioactive molecules targeting inflammatory and cardiovascular pathways. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on developing novel therapeutics and reference standards.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of prostaglandin-based active pharmaceutical ingredients (APIs) and their derivatives.
• Biochemical Research: Used as a reference standard and a probe in pharmacological studies to investigate eicosanoid signaling pathways, inflammation, and smooth muscle function.
• Drug Discovery: Serves as a core scaffold in medicinal chemistry programs aimed at developing new anti-inflammatory, cardiovascular, and ocular drugs.
• Analytical Standard: Employed in analytical method development and validation (e.g., HPLC, LC-MS) for quality control of prostaglandin-related compounds.
• Fine Chemical Synthesis: Used in multi-step organic synthesis to create specialized, high-value chemical entities for clinical trial materials.

Basic Information

Product Name	(4R,5E,7Z,12S,14Z)-4,12,20-Tris(Acetyloxy)-9-Oxo-5,7,10,14-Prostatetren-1-Oic Acid Methyl Ester
CAS No.	88216-93-7
Molecular Formula	C27H36O8
Molecular Weight	488.57 g/mol
Synonyms	Methyl 4,12,20-Triacetoxy-9-oxoprosta-5,7,10,14-tetraenoate; 9-Oxo-4,12,20-tris(acetyloxy)-5,7,10,14-prostatetetraenoic Acid Methyl Ester; Prostaglandin A2 Methyl Ester Triacetate; PGA2 Methyl Ester Triacetate; 4,12,20-Tri-O-acetyl-9-oxo-PGA2 Methyl Ester; (4R,5E,7Z,12S,14Z)-4,12,20-Triacetoxy-9-oxoprosta-5,7,10,14-tetraenoic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our (4R,5E,7Z,12S,14Z)-4,12,20-Tris(Acetyloxy)-9-Oxo-5,7,10,14-Prostatetren-1-Oic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and degradation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.