Description

(4R,5E,7E,12S,14Z)-4,12,20-Tris(Acetyloxy)-9-Oxo-5,7,10,14-Prostatetren-1-Oic Acid Methyl Ester is a high-purity synthetic prostaglandin derivative, a key intermediate in advanced pharmaceutical research and development. This compound is critical for its role in studying and modulating complex biological pathways related to inflammation, smooth muscle contraction, and cellular signaling. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in the fields of cardiovascular, reproductive, and inflammatory medicine.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of advanced prostaglandin analogs and related bioactive molecules.
• Biochemical Research: Used as a reference standard and active agent in studies of eicosanoid receptors, signal transduction, and enzyme inhibition assays.
• Drug Discovery: Serves as a core scaffold for medicinal chemistry programs aimed at developing new anti-inflammatory, vasoactive, or cytoprotective agents.
• Academic Research: Employed in university and institutional labs for investigating the physiological and pathophysiological roles of prostanoids.
• Process Development: Used in scaling up synthetic routes for prostaglandin-based Active Pharmaceutical Ingredients (APIs) under GMP conditions.

Basic Information

Product Name	(4R,5E,7E,12S,14Z)-4,12,20-Tris(Acetyloxy)-9-Oxo-5,7,10,14-Prostatetren-1-Oic Acid Methyl Ester
CAS No.	88216-92-6
Molecular Formula	C27H36O8
Molecular Weight	488.57 g/mol
Synonyms	Methyl (4R,5E,7E,12S,14Z)-4,12,20-triacetoxy-9-oxoprosta-5,7,10,14-tetraenoate; 9-Oxo-4,12,20-tris(acetyloxy)-5,7,10,14-prostatetren-1-oic Acid Methyl Ester; Prostaglandin A1 Methyl Ester Triacetate; PGA1 Methyl Ester Triacetate; (4R,5E,7E,12S,14Z)-4,12,20-Triacetoxy-9-oxoprosta-5,7,10,14-tetraenoic Acid Methyl Ester; 9-Keto-PGA1 Methyl Ester Triacetate
EINECS	Contact for details

Quality Control

Our (4R,5E,7E,12S,14Z)-4,12,20-Tris(Acetyloxy)-9-Oxo-5,7,10,14-Prostatetren-1-Oic Acid Methyl Ester is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing including HPLC, NMR, and mass spectrometry for identity confirmation and purity assessment. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.