Description

Gabaculine is a potent and selective inhibitor of γ-aminobutyric acid (GABA) transaminase, a key enzyme in the GABA metabolic pathway. This mechanism of action makes it a critical research tool for studying neurological processes and developing therapeutic interventions. It is primarily utilized by researchers and development teams in the pharmaceutical, biotechnology, and life science sectors for applications in neuroscience, drug discovery, and biochemical analysis.

Application

• Neuroscience Research: Used as a selective inhibitor to study the role of GABA metabolism, neurotransmission, and related neurological disorders.
• Drug Discovery & Development: Serves as a reference compound or lead molecule in the development of novel neuroactive pharmaceuticals targeting GABAergic systems.
• Biochemical Assay Development: Employed in enzymatic assays to specifically inhibit GABA transaminase activity for diagnostic or screening purposes.
• Metabolic Pathway Analysis: A key tool for probing and elucidating the GABA shunt and its connection to cellular metabolism in various biological models.
• Academic & Institutional Research: Utilized in university and research institute laboratories for fundamental studies in neurochemistry and neuropharmacology.

Basic Information

Product Name	Gabaculine
CAS No.	87980-11-8
Molecular Formula	C6H10N2O2
Molecular Weight	142.16 g/mol
Synonyms	3-Amino-2,3-dihydrobenzoic acid; 5-Amino-1,3-cyclohexadienylcarboxylic acid; GABA-T inhibitor; NSC 163501; (1,3-Cyclohexadien-5-yl)glycine; L-Gabaculine; 3-Amino-2,5-dihydrobenzoic acid
EINECS	Contact for details

Quality Control

Our Gabaculine is produced and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade biochemicals to guarantee reliable and reproducible results for your scientific work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.