Description

Fostriecin CAS NO 87810-56-8 is a potent and selective inhibitor of protein phosphatase 2A (PP2A) and protein phosphatase 4 (PP4), exhibiting significant antitumor and antibiotic activity. This compound is a critical research tool for studying cellular signaling pathways, particularly those involving serine/threonine phosphatases in cell cycle regulation and DNA damage response. It is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on oncology, cell biology, and the development of novel therapeutic agents.

Application

• Biomedical Research: A key pharmacological tool for investigating PP2A and PP4 signaling pathways in cell cycle control, apoptosis, and DNA repair mechanisms.
• Oncology Studies: Used in preclinical research to study its antitumor properties and potential as a lead compound for cancer therapy development.
• Signal Transduction Analysis: Essential for elucidating the role of specific phosphatases in various disease models and cellular processes.
• Antibiotic Research: Investigated for its antimicrobial activity against certain gram-positive bacteria.
• Biochemical Assay Development: Serves as a standard or control in high-throughput screening assays targeting phosphatase activity.
• Pharmaceutical Development: Used in early-stage drug discovery for structure-activity relationship (SAR) studies and mechanism-of-action validation.

Basic Information

Product Name	Fostriecin
CAS No.	87810-56-8
Molecular Formula	C₁₉H₃₂O₉P
Molecular Weight	444.43 g/mol
Synonyms	CI-920; PD 110,161; L-671,776; Antibiotic CI 920; Phospholine; (1R,2S,5R,6S,9S,10R,11S,14S)-5,9,11-Trihydroxy-2,10,12,12-tetramethyl-6-[(1E)-1-propen-1-yl]-3,16-dioxa-15-oxo-15λ⁵-phosphabicyclo[12.2.2]octadeca-7,17-dien-15-one
EINECS	Contact for details

Quality Control

Our Fostriecin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A Certificate of Analysis (COA) detailing specific results for purity, identity, and other critical parameters is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.