Description

Porfimer is a photosensitizing agent derived from hematoporphyrin, primarily used in photodynamic therapy (PDT). This compound is critical for targeted cancer treatments, where it selectively accumulates in malignant tissue and generates cytotoxic singlet oxygen upon activation with specific light wavelengths. It is essential for pharmaceutical manufacturers and research institutions developing advanced oncology therapies, particularly for treating esophageal, lung, and bladder cancers. The product is supplied as a high-purity active pharmaceutical ingredient (API) to ensure efficacy and safety in final drug formulations.

Application

• Photodynamic Therapy (PDT) Drug Manufacturing: As the core active pharmaceutical ingredient (API) in approved and investigational PDT drugs for various cancers.
• Oncology Research: Used in preclinical and clinical studies to investigate new PDT protocols, combination therapies, and mechanisms of action.
• Treatment of Obstructive Esophageal Cancer: A key component in therapies aimed at palliating dysphagia and improving quality of life.
• Treatment of Early-Stage Lung Cancer: Utilized in bronchoscopic PDT procedures for microinvasive endobronchial disease.
• Bladder Cancer Therapy: Applied in the treatment of carcinoma in situ (CIS) of the bladder.
• Dosage Form Development: Serves as a reference standard and raw material for formulating lyophilized powders for injection.

Basic Information

Product Name	Porfimer
CAS No.	87806-31-3
Molecular Formula	C₃₄H₃₀N₄O₄
Molecular Weight	558.63 g/mol
Synonyms	Porfimer Sodium; Dihematoporphyrin Ether; DHE; Photofrin (Brand Name); Hematoporphyrin Derivative; HpD; Porfimer Sodium (USP); CL-184116; NSC-684682
EINECS	Contact for details

Quality Control

Our Porfimer is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. Certificates of Analysis (COA) are provided, detailing results from tests such as HPLC assay, related substances, residual solvents, and endotoxin levels. We support compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopeial standards (USP/EP) for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C. The product is hygroscopic (moisture-sensitive) and strictly light-sensitive (protect from all light exposure). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake. Store in a dedicated, dry environment away from incompatible materials.

Specification

Item	Specification
Appearance	Dark red to reddish-brown powder or solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	NLT 95.0% and NMT 105.0%
Related Substances (HPLC)	Individual impurity: NMT 1.0% Total impurities: NMT 5.0%
Water Content (KF)	NMT 5.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	NMT 20 ppm
Endotoxin	NMT 5.0 EU/mg
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.