Description

Bz-Val-Gly-Arg-Amc Trifluoroacetate Salt is a synthetic peptide substrate designed for high-precision enzymatic research and diagnostic applications. This compound is critical for the study and quantification of protease activity, particularly thrombin and related serine proteases, due to its specific cleavage site. It is an essential reagent for pharmaceutical R&D, clinical diagnostics, and biochemical research where accurate enzyme kinetics are paramount.

Application

• Protease Activity Assays: Primary substrate for fluorometric detection of thrombin, trypsin, and other trypsin-like serine proteases in high-throughput screening (HTS).
• Pharmaceutical Research: Used in drug discovery for screening and characterizing protease inhibitors targeting coagulation and inflammatory pathways.
• Clinical Diagnostics: Key component in diagnostic kits for measuring plasma thrombin levels and other hemostatic parameters.
• Biochemical Research: Tool for studying enzyme kinetics, specificity, and catalytic mechanisms in academic and industrial laboratories.
• Quality Control: Employed in biomanufacturing to monitor and validate the activity of protease-containing products.

Basic Information

Product Name	Bz-Val-Gly-Arg-Amc Trifluoroacetate Salt
CAS No.	87779-49-5
Molecular Formula	C29H45N9O8 • C2HF3O2
Molecular Weight	Contact for details
Synonyms	Bz-Val-Gly-Arg-AMC TFA Salt; Benzoyl-Val-Gly-Arg-7-Amino-4-Methylcoumarin Trifluoroacetate; Boc-Val-Gly-Arg-AMC (common alias); Thrombin Substrate I (Fluorogenic); Bz-V-G-R-AMC; B2261 (common catalog number); Val-Gly-Arg-AMC derivative; Fluorogenic Peptide Substrate for Thrombin
EINECS	Contact for details

Quality Control

Our Bz-Val-Gly-Arg-Amc Trifluoroacetate Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance in sensitive assays. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and performance characteristics. We adhere to relevant quality guidelines suitable for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Functional Activity	Conforms to reference standard
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.