Description

24-Keto-1,23,25-Trihydroxyvitamin D3 is a high-purity, biologically active vitamin D3 metabolite and synthetic intermediate. This compound is critical for advanced pharmaceutical research and development, particularly in the study of calcium metabolism and endocrine signaling pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics for bone disorders, renal diseases, and endocrine dysfunctions.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the production of advanced vitamin D analogs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard and active compound in studies of vitamin D receptor (VDR) activation and metabolic pathways.
• Metabolite Standard: Serves as an analytical standard in LC-MS and HPLC methods for quantifying vitamin D metabolites in biological samples.
• Drug Discovery: Employed in high-throughput screening and lead optimization for new drugs targeting osteoporosis, psoriasis, and hyperparathyroidism.
• Cell Culture Studies: Applied in *in vitro* models to investigate cellular differentiation, proliferation, and gene expression regulated by vitamin D.

Basic Information

Product Name	24-Keto-1,23,25-Trihydroxyvitamin D3
CAS No.	87678-01-1
Molecular Formula	C₂₇H₄₂O₅
Molecular Weight	446.62 g/mol
Synonyms	1,23,25-Trihydroxy-24-oxovitamin D3; 24-Oxo-1,23,25-trihydroxyvitamin D3; 24-Ketocalcitriol; 24-Oxocalcitriol; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2S)-1,2-Dihydroxy-2-(3-hydroxy-3-methylbutyl)cyclopentyl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol
EINECS	Contact for details

Quality Control

Our 24-Keto-1,23,25-Trihydroxyvitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the stringent requirements for research and pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.