Description

3-Fluoro-2-Trimethylsilanyl-Pyridine is a high-value organosilicon building block featuring a pyridine ring substituted with fluorine and a trimethylsilyl group. This compound is critical for its role as a versatile intermediate in advanced organic synthesis, enabling the introduction of both fluorine and silicon functionalities into target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and the development of novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides where the fluorine atom enhances biological activity and stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to the reactive silicon group.
• Ligand Synthesis: Utilized for the preparation of novel nitrogen-containing ligands for catalysis and coordination chemistry.
• Fluorine Chemistry Research: An essential reagent in academic and industrial R&D focused on incorporating fluorine into complex organic frameworks.

Basic Information

Product Name	3-Fluoro-2-Trimethylsilanyl-Pyridine
CAS No.	87674-09-7
Molecular Formula	C9H14FNSi
Molecular Weight	183.30 g/mol
Synonyms	2-(Trimethylsilyl)-3-fluoropyridine; 3-Fluoro-2-(trimethylsilyl)pyridine; 3-Fluoro-2-trimethylsilylpyridine; Pyridine, 3-fluoro-2-(trimethylsilyl)-; 3-Fluoro-2-(TMS)pyridine; 3-F-2-TMS-Pyridine; 87674-09-7
EINECS	Contact for details

Quality Control

Our 3-Fluoro-2-Trimethylsilanyl-Pyridine is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality system supports development and cGMP production requirements for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.