Description

n-Alanylproline-o-(4-Nitrobenzoyl)Hydroxylamine is a specialized dipeptide-derived chemical building block featuring a nitrobenzoyl-protected hydroxylamine moiety. This compound is of significant value in advanced organic synthesis and pharmaceutical research, particularly for the development of enzyme inhibitors and novel bioactive molecules. It is primarily utilized by research scientists and process chemists in the pharmaceutical, biotechnology, and fine chemical industries for targeted molecular construction and medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential enzyme inhibitors, particularly targeting metalloproteases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of novel pharmacophores.
• Bioconjugation & Probe Development: Serves as a precursor for creating affinity probes or activity-based protein profiling (ABPP) reagents.
• Peptidomimetic Synthesis: Integral for constructing modified peptide analogs with enhanced stability or biological activity.
• Chemical Biology Tool: Employed in the study of hydroxylamine-dependent biochemical pathways and enzyme mechanisms.
• Fine Chemical Synthesis: Used as a specialized reagent in multi-step synthetic routes for complex organic molecules.

Basic Information

Product Name	n-Alanylproline-o-(4-Nitrobenzoyl)Hydroxylamine
CAS No.	87621-00-9
Molecular Formula	C15H18N4O6
Molecular Weight	350.33 g/mol
Synonyms	Ala-Pro-NH-O-CO-(4-NO2-Ph); N-[(2S)-1-[(2S)-2-Aminopropanoyl]pyrrolidin-2-yl]-N-hydroxy-4-nitrobenzamide; L-Alanyl-L-proline N-hydroxy-4-nitrobenzamide; Hydroxamic acid derivative of Ala-Pro; APNO; Peptidyl hydroxamate inhibitor precursor; 4-Nitrobenzoyl derivative of alanylproline hydroxamate
EINECS	Contact for details

Quality Control

Our n-Alanylproline-o-(4-Nitrobenzoyl)Hydroxylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.