Description

Taprostene Sodium is a stable, water-soluble sodium salt form of the prostacyclin analog, Taprostene. This compound is a potent and selective agonist of the IP receptor, making it a critical intermediate and reference standard in cardiovascular and pulmonary pharmacology research. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and academic institutions focused on developing novel therapeutics for hypertension, pulmonary arterial hypertension (PAH), and platelet aggregation disorders. Our supply ensures high purity and batch-to-batch consistency essential for reliable experimental and developmental work.

Application

• Pharmaceutical Reference Standard: Serves as a primary analytical standard for quality control and method validation in API (Active Pharmaceutical Ingredient) manufacturing.
• Cardiovascular Research: Used in in vitro and in vivo studies to investigate vasodilation, mechanisms of IP receptor activation, and treatments for systemic and pulmonary hypertension.
• Platelet Aggregation Studies: Employed as a research tool to study antiplatelet effects and pathways for preventing thrombosis.
• Preclinical Drug Development: Acts as a key intermediate or biological tool compound in the discovery and development of new prostacyclin-based therapies.
• Biochemical Assays: Utilized in high-throughput screening (HTS) and receptor binding assays to identify and characterize new drug candidates.

Basic Information

Product Name	Taprostene Sodium
CAS No.	87440-45-7
Molecular Formula	C₂₃H₃₁NaO₆
Molecular Weight	426.48 g/mol
Synonyms	Taprostene Sodium Salt; Sodium Taprostenate; Cicaprost Sodium Salt; 9β-Carbacyclin Sodium Salt; 5-[(1R,2R,3aS,9aS)-2-[(E)-3-Carboxyprop-1-enyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl]pentanoic Acid Sodium Salt; (1R,2R,3aS,9aS)-2-[(1E)-4-Carboxy-1-buten-1-yl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-1-pentanoic Acid Sodium Salt; ZK 36374 Sodium Salt
EINECS	Contact for details

Quality Control

Our Taprostene Sodium is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to maintain stability and potency. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm
Assay (on dried basis)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.