Description

1,25-Dihydroxy-23-Azavitamin D3 is a synthetic, nitrogen-modified analog of the biologically active form of vitamin D, designed for advanced research and development applications. This compound is of significant interest for its potential to modulate vitamin D receptor (VDR) signaling pathways with altered metabolic stability and selectivity. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotech companies engaged in the discovery of novel therapeutics for conditions related to calcium homeostasis, cell differentiation, and immune modulation.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of new vitamin D analogs for treating osteoporosis, psoriasis, and secondary hyperparathyroidism.
• Biochemical Pathway Studies: Used as a molecular probe to investigate the structure-activity relationship (SAR) of the vitamin D receptor and its role in gene expression and cell proliferation.
• Metabolism and Stability Studies: Employed in preclinical studies to assess the metabolic profile, pharmacokinetics, and degradation pathways of modified vitamin D compounds.
• Academic Research: Utilized in university laboratories for fundamental studies in endocrinology, oncology (investigating effects on cancer cell lines), and immunology.
• High-Purity Reference Material: Supplied as a certified reference standard for quality control and analytical method development in regulatory and compliance testing.

Basic Information

Product Name	1,25-Dihydroxy-23-Azavitamin D3
CAS No.	87407-70-3
Molecular Formula	C₂₇H₄₃NO₃
Molecular Weight	429.64 g/mol
Synonyms	23-Aza-1,25-dihydroxyvitamin D3; 23-Aza-1,25-dihydroxycholecalciferol; 1,25-Dihydroxy-23-azavitamin D₃; 23-Aza-1α,25-dihydroxyvitamin D3; 23-Aza-1α,25-dihydroxycholecalciferol; 23-Aza-calcitriol analog; 23-Nor-1,25-dihydroxyvitamin D3 derivative; 23-Aza-1,25-(OH)₂D₃
EINECS	Contact for details

Quality Control

Our 1,25-Dihydroxy-23-Azavitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. For specific purity requirements (e.g., >98%, >99%), please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at a controlled temperature of -20°C or below to maintain long-term stability and prevent oxidation. The container should be kept in a dry, cool, and well-ventilated area. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.