Description

Bryostatin 1, 35-Demethoxy-22,35-Epoxy-, (20R)- is a potent, semi-synthetic derivative of the naturally occurring bryostatin family of macrocyclic lactones. This compound is of significant interest for its role as a highly selective modulator of protein kinase C (PKC) isoforms, which is critical for advanced biomedical research and therapeutic development. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on oncology, neuroscience, and immunology.

Application

• Biomedical Research: A key tool compound for studying protein kinase C (PKC) signaling pathways, cellular differentiation, and apoptosis.
• Drug Discovery & Development: Serves as a lead compound or pharmacophore model for developing novel anti-cancer and neuroprotective agents.
• Oncology Research: Investigated for its potential to induce tumor cell death, enhance the efficacy of other chemotherapeutics, and overcome drug resistance.
• Neuroscience Studies: Explored for its ability to enhance synaptic plasticity, promote neurite outgrowth, and its potential application in treating neurodegenerative diseases like Alzheimer's.
• Immunology Research: Used in studies related to T-cell activation, immune response modulation, and potential HIV latency reversal.
• Chemical Biology: Employed as a molecular probe to understand complex biological processes and identify new therapeutic targets.

Basic Information

Product Name	Bryostatin 1, 35-Demethoxy-22,35-Epoxy-, (20R)-
CAS No.	87370-86-3
Molecular Formula	C45H68O16
Molecular Weight	865.0 g/mol
Synonyms	(20R)-Bryostatin 1; 35-Demethoxy-22,35-epoxybryostatin 1; 22,35-Epoxy-35-demethoxybryostatin 1; 35-Demethoxy-22,35-epoxy-(20R)-bryostatin 1; Bryostatin 1 derivative; PKC modulator; Macrocyclic lactone derivative
EINECS	Contact for details

Quality Control

Our Bryostatin 1 derivative is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to high-purity standards typical for research-grade biochemicals, with specifications available for review.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, desiccate to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.