Description

1,23,25-Trihydroxy-24-Oxo-Vitamin D3 is a biologically active metabolite of Vitamin D3, playing a crucial role in calcium and phosphate homeostasis. This compound is of significant interest for advanced research into bone metabolism, cellular differentiation, and endocrine regulation. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and manufacturers of high-purity reference standards and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Research & Development: A key intermediate or reference standard in the development of novel Vitamin D analogs and therapies for osteoporosis, psoriasis, and secondary hyperparathyroidism.
• Biochemical Research: Used in studies investigating the Vitamin D endocrine system, gene expression regulation, and cell signaling pathways.
• Reference Standard Manufacturing: Serves as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Metabolic Studies: Employed in preclinical and clinical research to understand the metabolic pathways and biological activity of Vitamin D3 derivatives.

Basic Information

Product Name	1,23,25-Trihydroxy-24-Oxo-Vitamin D3
CAS No.	87147-48-6
Molecular Formula	C₂₇H₄₂O₅
Molecular Weight	446.62 g/mol
Synonyms	24-Oxo-1,23,25-trihydroxyvitamin D3; 1,23,25-Trihydroxy-24-oxocholecalciferol; 24-Oxocalcitriol; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-Hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
EINECS	Contact for details

Quality Control

Our 1,23,25-Trihydroxy-24-Oxo-Vitamin D3 is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); therefore, containers must be kept sealed under inert atmosphere when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.