Description

(R)-Propranolol β-D-Glucuronide Sodium Salt is a high-purity, stereochemically defined metabolite reference standard of the β-blocker propranolol. This compound is critical for analytical research and method development in pharmaceutical and clinical laboratories, enabling precise quantification and metabolic profiling. It is primarily needed by researchers and quality control professionals in the pharmaceutical, contract research organization (CRO), and forensic toxicology sectors for applications such as bioanalytical method validation and drug metabolism and pharmacokinetics (DMPK) studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of (R)-propranolol glucuronide in drug substance and product testing.
• Bioanalytical Method Development & Validation: Essential for developing and validating sensitive HPLC-MS/MS or LC-UV methods for pharmacokinetic studies and therapeutic drug monitoring.
• Metabolite Research: Serves as a key tool in studying the stereoselective metabolism and pharmacokinetics of propranolol enantiomers.
• Clinical Toxicology: Employed as a calibrator or control in assays to detect and quantify propranolol and its metabolites in human plasma or serum.
• Enzyme Activity Assays: Used as a specific substrate for investigating the activity of UDP-glucuronosyltransferase (UGT) enzymes in vitro.
• Impurity Profiling: Acts as a known impurity standard for ensuring the purity of propranolol active pharmaceutical ingredient (API) according to ICH guidelines.

Basic Information

Product Name	(R)-Propranolol β-D-Glucuronide Sodium Salt
CAS No.	87102-70-3
Molecular Formula	C22H34NNaO8
Molecular Weight	463.50 g/mol
Synonyms	(R)-Propranolol Glucuronide Sodium Salt; (R)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol β-D-Glucopyranosiduronic Acid Sodium Salt; Sodium (2R)-1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol β-D-glucopyranosiduronate; (R)-Propranolol O-β-D-Glucuronide Sodium; Dexpropranolol Glucuronide Sodium Salt
EINECS	Contact for details

Quality Control

Every batch of (R)-Propranolol β-D-Glucuronide Sodium Salt is manufactured and analyzed under strict quality management systems. Our products undergo rigorous identity, purity, and assay testing using advanced techniques like HPLC, NMR, and mass spectrometry to ensure compliance with the high standards required for reference materials. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for purity, chiral purity, water content, and residual solvents is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R-enantiomer)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.