Description

Leptomycin A CAS NO 87081-36-5 is a potent and specific inhibitor of nuclear export signal (NES)-dependent protein transport, acting as a covalent inhibitor of the exportin CRM1. This compound is a critical research tool in molecular biology and oncology for studying nucleocytoplasmic transport, cell cycle regulation, and apoptosis. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies investigating cancer mechanisms and developing novel therapeutic strategies.

Application

• Biomedical Research: A fundamental tool for studying CRM1-mediated nuclear export pathways and their role in cellular signaling.
• Oncology Research: Used to investigate the dysregulation of tumor suppressor proteins and oncogenes due to aberrant nuclear export in cancer cells.
• Drug Discovery: Serves as a reference compound and a starting point for the development of novel anti-cancer agents targeting the CRM1 export pathway.
• Virology Studies: Employed to understand how viruses hijack host cell nuclear export machinery for viral replication and assembly.
• Cell Biology Assays: Used to validate the subcellular localization of proteins and to probe mechanisms of cell cycle arrest and apoptosis.

Basic Information

Product Name	Leptomycin A
CAS No.	87081-36-5
Molecular Formula	C33H46O6
Molecular Weight	538.72 g/mol
Synonyms	Leptomycin A; LMB-A; (3R,4S,5S,6R,8S,9S,10E,12E,15S,17S)-17-Ethyl-4,6,8,15-tetrahydroxy-5,9,13,15-tetramethyl-10,12-hexadecadien-17-olide; CRM1 Inhibitor I; Antibiotic CI 940; Streptomyces metabolite inhibitor of protein export
EINECS	Contact for details

Quality Control

Our Leptomycin A is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity confirmation and structural verification via spectroscopic methods. A detailed Certificate of Analysis (COA) containing purity, identity, and impurity profiles is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, ethanol, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.