Description

Leptomycin B CAS NO 87081-35-4 is a potent and specific inhibitor of nuclear export signal (NES)-dependent protein transport, functioning as a covalent inhibitor of CRM1/exportin 1. This compound is a critical research tool in molecular biology and oncology for studying nucleocytoplasmic transport, cell cycle regulation, and apoptosis. It is essential for academic researchers, pharmaceutical R&D teams, and biotechnology companies focused on cancer mechanisms, virology, and the development of novel therapeutic agents.

Application

• Biomedical Research: Used as a highly specific CRM1 inhibitor to study nuclear export mechanisms, protein localization, and signal transduction pathways in cell models.
• Oncology & Cancer Research: Investigated for its ability to induce cell cycle arrest and apoptosis in various cancer cell lines, serving as a lead compound for anticancer drug discovery.
• Virology Studies: Employed to block the nuclear export of viral proteins and RNAs, making it a valuable tool for understanding the life cycle of viruses like HIV and influenza.
• Pharmaceutical Development: Acts as a reference standard and pharmacological probe in high-throughput screening assays and preclinical studies targeting CRM1.
• Cell Biology & Biochemistry: Essential for experiments requiring the forced nuclear retention of proteins to elucidate their function in transcription, DNA repair, and stress response.

Basic Information

Product Name	Leptomycin B
CAS No.	87081-35-4
Molecular Formula	C₃₃H₄₅ClO₆
Molecular Weight	573.17 g/mol
Synonyms	LMB; Leptomycin B from *Streptomyces*; (2E,4E,6R,7S,8E,10E,12E,14R,16S)-7-Ethyl-4,6,8,10,12,14,16-heptamethyl-17-(2-oxooxolan-3-yl)-2-(propan-2-ylidene)heptadeca-2,4,8,10,12-pentaen-6-olide; CRM1 Inhibitor; Antibiotic L 681,110; Antibiotic L 681110; Exportin 1 Inhibitor
EINECS	Contact for details

Quality Control

Our Leptomycin B is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation, identity verification by spectroscopic methods (IR, NMR), and impurity profiling. Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, ethanol, methanol
Biological Activity (IC₅₀)	Reported value provided per batch

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.