Description

4'-Hydroxypentobarbitone is a specific hydroxylated derivative of the barbiturate class, identified by CAS No. 87079-96-7. This compound is of significant interest in pharmaceutical research and development, particularly for its role as a key intermediate or metabolite in the study of central nervous system (CNS) agents. It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical companies engaged in drug discovery, metabolic pathway analysis, and the synthesis of specialized chemical reference standards.

Application

• Pharmaceutical Research Intermediate: Serves as a critical building block in the synthesis and study of novel barbiturate-derived compounds.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical methods (e.g., LC-MS, HPLC) for the identification and quantification of pentobarbitone metabolites in pharmacokinetic and toxicological studies.
• Biochemical Research: Employed in in-vitro studies to investigate the structure-activity relationships (SAR) and metabolic pathways of sedative-hypnotic drugs.
• Analytical Chemistry: Acts as a high-purity calibrant or reference material for quality control laboratories ensuring accuracy in pharmaceutical analysis.
• Chemical Synthesis: Utilized by fine chemical manufacturers for the custom synthesis of specialized derivatives for research purposes.

Basic Information

Product Name	4'-Hydroxypentobarbitone
CAS No.	87079-96-7
Molecular Formula	C11H16N2O4
Molecular Weight	240.26 g/mol
Synonyms	5-Ethyl-5-(3-hydroxy-1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-(1-Methyl-3-hydroxybutyl)-5-ethylbarbituric Acid; 4'-Hydroxy-5-ethyl-5-(1-methylbutyl)barbituric Acid; 4'-OH-Pentobarbital; Pentobarbitone 4'-Hydroxy Metabolite
EINECS	Contact for details

Quality Control

Our 4'-Hydroxypentobarbitone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by chromatographic techniques (HPLC). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.