Description

Bradykinin Chloromethyl Ketone is a potent and selective synthetic peptide inhibitor designed to irreversibly inactivate kallikrein and related serine proteases. This compound is a critical research tool for studying the complex pathways of the kallikrein-kinin system, inflammation, and blood pressure regulation. It is essential for pharmaceutical R&D, biochemical research, and proteomics studies focused on developing novel therapeutic agents.

Application

• Protease Inhibition Research: Acts as an irreversible active-site titrant and inhibitor for plasma kallikrein, tissue kallikrein, and other related serine proteases.
• Kinin System Studies: A fundamental tool for investigating the physiological and pathological roles of bradykinin, including inflammation, pain, and vascular permeability.
• Drug Discovery & Development: Used in high-throughput screening and mechanistic studies to identify and validate new targets for cardiovascular, inflammatory, and pain disorders.
• Biochemical Assay Development: Serves as a standard and control in enzymatic assays to measure kallikrein activity and evaluate potential inhibitors.
• Academic & Pharmaceutical R&D: Supports basic research in universities, research institutes, and biopharmaceutical companies exploring novel therapeutic pathways.

Basic Information

Product Name	Bradykinin Chloromethyl Ketone
CAS No.	86807-97-8
Molecular Formula	C50H78N14O11S
Molecular Weight	1051.3 g/mol
Synonyms	Bradykinin Potentiator B2; Kallikrein Inhibitor; D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Phe-Thi-Arg-CH2Cl; H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Phe-Thi-Arg-CH2Cl; Bradykinin, 9-[Nα-(chloroacetyl)-D-phenylalanyl]-8-L-thienylalanyl-; B-4148; Kallidinogenase Inhibitor; Bradykinin Chloromethyl Ketone (TFA)
EINECS	Contact for details

Quality Control

Our Bradykinin Chloromethyl Ketone is produced under stringent quality protocols to ensure high purity and batch-to-batch consistency for research applications. Each lot is characterized by advanced analytical techniques including HPLC, MS, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 98% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.