Description

Argipressin, D(Ch2)5-Phe(2,4)- is a synthetic analog of the neurohypophysial hormone arginine vasopressin, designed with specific structural modifications to enhance its stability and receptor-binding profile. This compound is of significant interest for advanced research and development in peptide-based therapeutics. It is primarily utilized by pharmaceutical researchers and manufacturers focused on endocrinology, metabolic disorders, and cardiovascular research.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel vasopressin receptor agonists and antagonists.
• Biochemical Research: Used in in vitro and in vivo studies to investigate the V1a and V2 receptor signaling pathways, cellular responses, and physiological effects related to water retention and vasoconstriction.
• Drug Discovery Programs: Serves as a crucial building block or a lead compound for structure-activity relationship (SAR) studies aimed at creating more selective and metabolically stable peptide therapeutics.
• Diagnostic Agent Development: Potential use in the formulation of diagnostic tools or radiopharmaceuticals for imaging vasopressin receptor expression in certain conditions.

Basic Information

Product Name	Argipressin, D(Ch2)5-Phe(2,4)-
CAS No.	86785-94-6
Molecular Formula	C46H65N13O12S2
Molecular Weight	1040.2 g/mol
Synonyms	[1-(β-Mercapto-β,β-pentamethylenepropionic acid), 2-(O-methyl-L-tyrosine), 4-L-valine, 8-D-arginine]vasopressin; Desmopressin analog; d(CH2)5[Tyr(Me)^2,Val^4,Arg^8]vasopressin; V1a Vasopressin Receptor Antagonist; SK&F 100273; [1-β-Mercapto-β,β-cyclopentamethylenepropionic acid),2-O-methyltyrosine,4-valine,8-D-arginine]vasopressin
EINECS	Contact for details

Quality Control

Our Argipressin, D(Ch2)5-Phe(2,4)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and related substances. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis to meet specific purity requirements (e.g., >95%, >98%) is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Solubility	Soluble in water, acetic acid; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.