Description

(+)-Cisapride CAS NO 86718-70-9 is the pharmacologically active enantiomer of the benzamide derivative cisapride. This compound is of significant interest in pharmaceutical research and development due to its specific mechanism of action as a serotonin 5-HT4 receptor agonist, which promotes gastrointestinal motility. It is primarily utilized by pharmaceutical companies, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the synthesis of advanced intermediates, reference standards, and novel therapeutic agents targeting gastrointestinal disorders.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of proprietary gastrointestinal prokinetic agents.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) testing in pharmaceutical laboratories.
• Biochemical Research: A tool compound for studying serotonin receptor (5-HT4) pharmacology and signal transduction pathways.
• Formulation Development: Serves as an active pharmaceutical ingredient (API) in preclinical and clinical formulation studies.
• Metabolite Synthesis: Used in the preparation of metabolite standards for pharmacokinetic and toxicology studies.
• Contract Manufacturing: Supplied to CDMOs for the production of specialized, small-batch pharmaceutical products.

Basic Information

Product Name	(+)-Cisapride
CAS No.	86718-70-9
Molecular Formula	C23H29ClFN3O4
Molecular Weight	465.95 g/mol
Synonyms	(+)-Cisapride; (3S,4R)-Cisapride; Dexcisapride; (S)-(+)-Cisapride; 4-Amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide; UNII-6H631L4A9Y; R 51619; CJM 208
EINECS	Contact for details

Quality Control

Our (+)-Cisapride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing specifications such as enantiomeric excess (ee), chemical purity (by HPLC), and residual solvents are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.