Description

24-Fluoro-1,25-Dihydroxycholecalciferol is a fluorinated analog of the active form of Vitamin D3, designed to modulate calcium and phosphate metabolism with potentially enhanced metabolic stability. This compound is of significant interest for its role in research focused on bone health, cellular differentiation, and immune system regulation. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers developing novel therapeutics for metabolic bone diseases, psoriasis, and certain cancers.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of new Vitamin D receptor (VDR) modulators.
• Metabolic Bone Disease Studies: Investigated for potential therapeutic applications in conditions like osteoporosis, renal osteodystrophy, and hypoparathyroidism due to its calcemic activity.
• Dermatology Research: Used in studies exploring treatments for psoriasis and other hyperproliferative skin disorders, leveraging the antiproliferative effects of Vitamin D analogs.
• Oncology Research: Employed in preclinical research for its potential to induce cell differentiation and apoptosis in certain cancer cell lines, including leukemic and colon cancer cells.
• Biochemical Tool Compound: Acts as a selective ligand in studies of Vitamin D receptor structure, function, and signaling pathways.
• Fine Chemical Synthesis: Used as a high-value building block for the synthesis of more complex, targeted Vitamin D analogs and prodrugs.

Basic Information

Item	Detail
Product Name	24-Fluoro-1,25-Dihydroxycholecalciferol
CAS No.	86677-62-5
Molecular Formula	C₂₇H₄₃FO₃
Molecular Weight	434.63 g/mol
Synonyms	24-Fluoro-1,25-dihydroxyvitamin D3; 24-Fluoro-calcitriol; 1,25-Dihydroxy-24-fluorocholecalciferol; 24-F-1,25-(OH)₂D₃; Falecalcitriol (related analog); 24-Fluorocalcitriol; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol, 24-fluoro-
EINECS	Contact for details

Quality Control

Our 24-Fluoro-1,25-Dihydroxycholecalciferol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets exacting standards for research and development use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.