Description

10-Nitrocamptothecin is a potent synthetic derivative of the natural alkaloid camptothecin, designed to enhance its pharmacological profile. This compound is a critical intermediate and active pharmaceutical ingredient (API) in the development of novel anticancer therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology firms, and academic research institutions focused on oncology drug discovery and mechanism studies.

Application

• Anticancer Drug Development: Serves as a key intermediate in the synthesis of advanced camptothecin analogs targeting topoisomerase I inhibition.
• Biochemical Research: Used as a reference standard and tool compound for studying apoptosis, DNA damage, and cell cycle arrest in cancer cell lines.
• Pharmaceutical R&D: Employed in preclinical studies to evaluate the efficacy, pharmacokinetics, and structure-activity relationships (SAR) of new chemotherapeutic agents.
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry and experimental oncology.
• API Manufacturing: Acts as a high-purity starting material or intermediate for the production of finished dosage forms in GMP environments.

Basic Information

Product Name	10-Nitrocamptothecin
CAS No.	86639-62-5
Molecular Formula	C20H15N3O6
Molecular Weight	393.35 g/mol
Synonyms	10-Nitro-camptothecin; (S)-10-Nitrocamptothecin; 10-NCPT; Camptothecin, 10-nitro-; (19S)-10-Nitrocamptothecin; 4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
EINECS	Contact for details

Quality Control

Our 10-Nitrocamptothecin is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to meet exacting internal standards, specifications can be aligned with client requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) or as specified on the label or COA. The material is light-sensitive and easily oxidized; prolonged exposure to air, light, or moisture should be avoided.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.