Description

7-Propyl-10-Hydroxycamptothecin is a semi-synthetic derivative of the natural alkaloid camptothecin, designed to enhance therapeutic efficacy and stability. This compound is a critical intermediate and active pharmaceutical ingredient (API) in the development of potent topoisomerase I inhibitors for oncology applications. It is essential for pharmaceutical manufacturers and research institutions focused on creating advanced chemotherapeutic agents targeting various solid tumors.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel camptothecin-based anticancer drugs.
• Oncology Research: Used as a reference standard and active compound in preclinical studies to investigate mechanisms of topoisomerase I inhibition and apoptosis.
• API Manufacturing: Employed as an active pharmaceutical ingredient in the formulation of injectable and oral dosage forms for clinical trials and commercial production.
• Drug Discovery: A vital scaffold for medicinal chemistry programs aimed at developing next-generation chemotherapeutics with improved solubility and reduced toxicity profiles.
• Biochemical Reagent: Utilized in biochemical assays to study DNA replication and repair processes.

Basic Information

Product Name	7-Propyl-10-Hydroxycamptothecin
CAS No.	86639-55-6
Molecular Formula	C23H22N2O5
Molecular Weight	406.44 g/mol
Synonyms	10-Hydroxy-7-propylcamptothecin; 7-Propyl-10-hydroxycamptothecin; SN-38 Propyl Derivative; CPT-11 Active Metabolite Analog; (S)-10-Hydroxy-7-propylcamptothecin; Irinotecan Metabolite Derivative; 7-Propyl-10-HCPT
EINECS	Contact for details

Quality Control

Our 7-Propyl-10-Hydroxycamptothecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by spectroscopic methods, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to meet specific pharmacopeial or client specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.