Description

Camptothecin 1-Oxide is a significant oxidized derivative of the potent topoisomerase I inhibitor, camptothecin. This compound is valued for its role as a key intermediate and reference standard in advanced pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the oncology and life sciences sectors for studying drug metabolism, synthesizing novel analogs, and developing targeted cancer therapeutics.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of more complex camptothecin-derived anticancer agents.
• Biochemical Research: Used as a reference standard and probe in studies of topoisomerase I inhibition mechanisms and structure-activity relationships (SAR).
• Metabolite Studies: Serves as a model compound for investigating the metabolic pathways and biotransformation of camptothecin-based drugs.
• Analytical Standard: Employed in HPLC, LC-MS, and other analytical methods for quality control and quantification in pharmaceutical development.
• Anticancer Agent Development: Investigated for its own biological activity and as a building block for creating new chemotherapeutic candidates with improved efficacy or reduced side effects.

Basic Information

Product Name	Camptothecin 1-Oxide
CAS No.	86639-48-7
Molecular Formula	C20H16N2O6
Molecular Weight	380.35 g/mol
Synonyms	1-Oxocamptothecin; Camptothecin N-Oxide; CPT 1-Oxide; (S)-Camptothecin 1-Oxide; 4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 1-Oxide; NSC 100880; Camptothecin, 1-oxide
EINECS	Contact for details

Quality Control

Our Camptothecin 1-Oxide is produced and tested under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our global clientele in pharmaceutical and analytical fields.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.