Description

Misonidazole Glucuronide is a key metabolite and reference standard of the radiosensitizer Misonidazole. This compound is critical for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the efficacy of nitroimidazole-based therapeutic agents. It is primarily utilized by research institutions, pharmaceutical companies, and CROs (Contract Research Organizations) engaged in oncology drug development and analytical method validation.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the qualitative and quantitative analysis of Misonidazole and its metabolites in biological matrices.
• Metabolite Identification & Profiling: Essential for ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand the metabolic pathways of nitroimidazole drugs.
• Bioanalytical Method Development: Serves as a critical component in developing and validating HPLC, LC-MS, and other chromatographic assays for pharmacokinetic studies.
• Oncology Research: Supports research into the mechanism of action and metabolic fate of radiosensitizing agents used in cancer therapy.
• Quality Control & Impurity Testing: Employed in pharmaceutical QC laboratories to identify and quantify process-related impurities and degradation products.

Basic Information

Product Name	Misonidazole Glucuronide
CAS No.	86589-32-4
Molecular Formula	C15H20N4O9
Molecular Weight	400.34 g/mol
Synonyms	1-(2-Nitro-1-imidazolyl)-3-methoxy-2-propanol Glucuronide; Misonidazole β-D-Glucuronide; MISO Glucuronide; Ro 07-9963/007; 1-(2-Nitroimidazol-1-yl)-3-methoxypropan-2-ol Glucuronide; Misonidazole Metabolite Glucuronide; NSC 261036 Glucuronide
EINECS	Contact for details

Quality Control

Our Misonidazole Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.