Description

Calcitonin, Salmon, Des-Leu(16)- CAS NO 86370-00-5 is a synthetic analog of salmon calcitonin, a polypeptide hormone with a specific amino acid deletion. This modification can enhance its metabolic stability and receptor binding profile, making it a valuable research-grade biochemical. It is primarily utilized in pharmaceutical research and development, particularly in studies related to calcium metabolism, bone disorders, and endocrine function. This high-purity peptide is essential for scientists and manufacturers developing novel therapeutic agents and diagnostic tools.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control and assay validation in drug manufacturing.
• Biomedical Research: Serves as a critical tool in in vitro and in vivo studies investigating bone resorption, calcium homeostasis, and osteoporosis mechanisms.
• Peptide Chemistry Studies: Employed in structure-activity relationship (SAR) research to understand the impact of specific amino acid deletions on peptide hormone activity and stability.
• Analytical Method Development: Used to develop and calibrate analytical methods such as HPLC and mass spectrometry for peptide quantification and identification.
• Preclinical Formulation Development: Acts as an active pharmaceutical ingredient (API) analog in early-stage formulation studies for potential calcitonin-based therapies.

Basic Information

Product Name	Calcitonin, Salmon, Des-Leu(16)- CAS NO 86370-00-5
CAS No.	86370-00-5
Molecular Formula	C₁₄₅H₂₄₀N₄₄O₄₈S₂
Molecular Weight	~3417.9 g/mol
Synonyms	Des-Leu16-Salmon Calcitonin; [Des-Leucine16]-Calcitonin (salmon); Salmon Calcitonin (1-32), 16-Deleucine-; UNII-6E5N5L5K6U; H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH₂ (Disulfide bridge: 1-7)
EINECS	Contact for details

Quality Control

Our Calcitonin, Salmon, Des-Leu(16)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all specification parameters to ensure compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant use and maintain the container under inert atmosphere after opening to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Peptide Content	≥ 80.0%
Acetate Content (HPIC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.