Description

4-(2-Carboxyethenyl)-2-Methoxyphenyl β-D-Glucopyranosiduronic Acid is a high-purity, conjugated glucuronide metabolite of significant interest in advanced biochemical research and pharmaceutical development. This compound is crucial for studying drug metabolism pathways, particularly as a reference standard for pharmacokinetic and toxicological analyses. It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical companies engaged in metabolite identification, biomarker discovery, and the development of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quantification and validation of drug metabolites in bioanalytical methods.
• Drug Metabolism & Pharmacokinetics (DMPK): Used in in vitro and in vivo studies to elucidate Phase II conjugation pathways and understand the glucuronidation of parent drug molecules.
• Toxicology Studies: Employed as a biomarker or analytical standard in assessing the metabolic fate and potential toxicity of new chemical entities.
• Enzymatic Activity Assays: Acts as a substrate or standard in assays for UDP-glucuronosyltransferase (UGT) enzyme activity and inhibition studies.
• Biomarker Research: Applied in the discovery and validation of metabolic biomarkers for disease states or drug exposure.
• Method Development & Validation: Essential for developing and calibrating advanced analytical techniques such as LC-MS/MS and HPLC in regulatory bioanalysis.

Basic Information

Product Name	4-(2-Carboxyethenyl)-2-Methoxyphenyl β-D-Glucopyranosiduronic Acid
CAS No.	86321-24-6
Molecular Formula	C16H18O10
Molecular Weight	370.31 g/mol
Synonyms	(2E)-3-[2-Methoxy-4-[(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(carboxyoxy)oxan-2-yl]oxyphenyl]prop-2-enoic acid; 4-(2-Carboxyvinyl)-2-methoxyphenyl β-D-glucopyranosiduronic acid; Ferulic acid 4-O-β-D-glucuronide; Ferulic acid glucuronide; trans-Ferulic acid glucuronide; FA glucuronide; (E)-Ferulic acid 4-O-glucuronide
EINECS	Contact for details

Quality Control

Our 4-(2-Carboxyethenyl)-2-Methoxyphenyl β-D-Glucopyranosiduronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.