Description

n-Desmethylmetaclazepam is a key benzodiazepine derivative and a primary metabolite of metaclazepam. This compound is of significant interest in pharmaceutical research and development, particularly in the study of drug metabolism and the synthesis of novel therapeutic agents. It serves as a critical intermediate and reference standard for analytical laboratories, toxicology studies, and the development of new central nervous system (CNS) active pharmaceuticals.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of metaclazepam and its metabolites in bioanalytical studies.
• Metabolite Research: Essential for pharmacokinetic and pharmacodynamic studies to understand the metabolic pathway and activity of metaclazepam.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a high-purity building block in the synthesis of advanced benzodiazepine derivatives and potential new drug candidates.
• Forensic and Clinical Toxicology: Employed as an analytical standard in forensic labs and hospitals for accurate drug testing and monitoring.
• Academic and R&D Laboratories: Used in university and institutional research for neuropharmacology studies and method development.
• Quality Control: Acts as a critical component in the quality assurance and control processes of pharmaceutical manufacturers.

Basic Information

Product Name	n-Desmethylmetaclazepam
CAS No.	86298-26-2
Molecular Formula	C17H15ClN2O2
Molecular Weight	314.77 g/mol
Synonyms	7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; Nor-Metaclazepam; Desmethylmetaclazepam; 1-Desmethylmetaclazepam; Metaclazepam Impurity; Metaclazepam Metabolite; Ro 07-9749/000
EINECS	Contact for details

Quality Control

Our n-Desmethylmetaclazepam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed results for all critical parameters, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates and reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.