Description

3,5-Dimethylbenzenesulfonyl Fluoride is a specialized organosulfur compound featuring a reactive sulfonyl fluoride group. This high-purity chemical intermediate is valued for its role as a key building block in advanced organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. It is primarily sought after by research institutions and industrial manufacturers engaged in medicinal chemistry, proteomics research, and the synthesis of novel materials.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), especially for sulfonamide-based drugs.
• Chemical Proteomics & Bioconjugation: Used as a reactive handle for activity-based protein profiling (ABPP) and covalent inhibitor development due to the selectivity of the sulfonyl fluoride group.
• Agrochemical Synthesis: Serves as an intermediate in the production of herbicides, fungicides, and other crop protection agents.
• Material Science: Employed in the research and development of advanced polymers and functional materials.
• Organic Synthesis Reagent: Acts as a versatile reagent for introducing the 3,5-dimethylphenylsulfonyl moiety into target molecules.
• Cross-coupling Reactions: Can be utilized in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.

Basic Information

Product Name	3,5-Dimethylbenzenesulfonyl Fluoride
CAS No.	86146-00-1
Molecular Formula	C8H9FO2S
Molecular Weight	188.22 g/mol
Synonyms	3,5-Dimethylbenzenesulfonyl fluoride; 3,5-Dimethylphenylsulfonyl fluoride; 1,3-Dimethyl-5-fluorosulfonylbenzene; m-Xylene-5-sulfonyl fluoride; 3,5-Dimethylbenzene-1-sulfonyl fluoride; 3,5-Dimethylbenzenesulphonyl fluoride; 3,5-Dimethylphenyl sulfonyl fluoride
EINECS	Contact for details

Quality Control

Our 3,5-Dimethylbenzenesulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of research and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.