Description

n-Ethyl-2,2,2-D3-Aniline is a deuterium-labeled isotopologue of N-ethylaniline, where three hydrogen atoms on the ethyl group are replaced with deuterium. This compound is a critical stable isotope-labeled standard used for precise quantification and metabolic pathway tracing in advanced analytical chemistry. It is primarily required by research institutions and pharmaceutical companies engaged in drug development, environmental analysis, and mass spectrometry-based proteomics.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a quantitative reference standard in LC-MS and GC-MS analysis for accurate measurement of N-ethylaniline and related compounds.
• Pharmaceutical Research & Development: Used in pharmacokinetic (PK) and drug metabolism studies as a tracer to understand the absorption, distribution, metabolism, and excretion (ADME) of parent compounds.
• Metabolomics and Proteomics: Enables precise relative and absolute quantification in complex biological samples for biomarker discovery and pathway analysis.
• Environmental and Food Safety Testing: Acts as a high-purity standard in the detection and quantification of aniline derivatives in environmental samples and food products.
• Chemical Synthesis Research: Employed as a labeled building block in the synthesis of more complex deuterated molecules for mechanistic studies.
• Quality Control and Method Validation: Essential for developing and validating robust analytical methods in compliance with Good Laboratory Practice (GLP) and ICH guidelines.

Basic Information

Product Name	n-Ethyl-2,2,2-D3-Aniline
CAS No.	86099-77-6
Molecular Formula	C8H8D3N
Molecular Weight	124.19 g/mol
Synonyms	N-Ethyl-2,2,2-d3-aniline; N-Ethyl-d3-aniline; Deuterated N-ethylaniline; Ethyl-d3-aniline; (2,2,2-D3)Ethylaniline; N-(2,2,2-Trideuteroethyl)aniline; N-Ethyl-2,2,2-trideuteroaniline; N-Ethylaniline-d3
EINECS	Contact for details

Quality Control

Our n-Ethyl-2,2,2-D3-Aniline is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, meeting the stringent requirements of analytical and research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D-atom %), chemical purity (by GC and/or HPLC), and identity confirmation (by NMR and MS). We support compliance with ISO, GLP, and REACH standards, and specifications can be tailored for specific research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR / NMR)	Conforms to structure
Purity (GC / HPLC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 99.0% at D3 position
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.