Description

5-Nitroprostaglandin I2 is a chemically modified analog of prostacyclin (PGI2), a potent vasodilator and inhibitor of platelet aggregation. This nitrated derivative is primarily utilized as a key research compound in cardiovascular and pharmacological studies to investigate the structure-activity relationships of prostanoids. It is essential for researchers and pharmaceutical developers in the life sciences sector, particularly those focused on vascular biology, thrombosis, and the development of novel therapeutic agents targeting the prostacyclin pathway.

Application

• Pharmacological Research: Used as a reference standard and active compound in studies exploring the mechanisms of vasodilation, platelet inhibition, and vascular homeostasis.
• Drug Discovery & Development: Serves as a critical intermediate or lead compound in the synthesis and screening of new cardiovascular and anti-thrombotic drugs.
• Biochemical Assays: Employed in in vitro and cell-based assays to study receptor binding, signal transduction, and the biological effects of prostacyclin analogs.
• Academic & Institutional Research: A vital tool for universities and research institutes conducting fundamental research on eicosanoid biology and vascular physiology.
• Reference Material: Provides a high-purity standard for analytical methods such as HPLC and LC-MS in quality control and metabolic studies.

Basic Information

Product Name	5-Nitroprostaglandin I2
CAS No.	86022-39-1
Molecular Formula	C₂₀H₃₁NO₆
Molecular Weight	381.47 g/mol
Synonyms	5-Nitro-PGI2; 5-Nitroprostacyclin I2; 5-Nitro-PGI₂; 9-Deoxy-9α,11α-epoxy-5-nitro-15α-hydroxy-13,14-dihydro-16-phenoxy-17,18,19,20-tetranorprosta-4,5,13-trienoic Acid; 5-Nitro Prostaglandin I2; 5-Nitro Prostacyclin; 5-Nitro PGI2; 5-Nitro PGI₂
EINECS	Contact for details

Quality Control

Our 5-Nitroprostaglandin I2 is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and specifications can be provided to meet the specific requirements of your analytical protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. For long-term storage, keep desiccated under an inert atmosphere. Allow the product to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.