Description

3-(Difluoromethoxy)Benzaldehyde is a versatile aromatic aldehyde building block characterized by a difluoromethoxy substituent, which imparts unique electronic and metabolic stability properties. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where the introduction of fluorine atoms is a key strategy to modulate biological activity and improve product performance. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the difluoromethoxy group enhances lipophilicity and biological efficacy.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for advanced display technologies.
• Organic Electronics: Employed in the construction of conjugated molecules and polymers for organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Research: A valuable reagent for exploring new fluorination methodologies and as a building block in cross-coupling reactions and nucleophilic aromatic substitution.
• Flavor & Fragrance Intermediate: Used in the synthesis of complex aromatic compounds for specialty fragrance applications.

Basic Information

Product Name	3-(Difluoromethoxy)Benzaldehyde
CAS No.	85684-61-3
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	m-(Difluoromethoxy)benzaldehyde; 3-(Difluoromethoxy)benzaldehyde; Benzaldehyde, 3-(difluoromethoxy)-; α,α-Difluoro-m-anisaldehyde; 1-(Difluoromethoxy)-3-formylbenzene; 3-Formylphenyl difluoromethyl ether; Difluoromethoxybenzaldehyde-3; Meta-difluoromethoxybenzaldehyde
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)Benzaldehyde is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, and we support audits and regulatory documentation as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.