Description

12-o-Undecadienoylphorbol-13-Acetate is a specific, high-purity derivative of phorbol, a complex diterpene ester known for its potent biological activity. This compound is of significant interest in advanced biochemical and pharmacological research due to its role as a specific modulator of protein kinase C (PKC) and other signaling pathways. It is primarily utilized by research institutions and pharmaceutical development laboratories focused on oncology, dermatology, and cell signaling mechanisms.

Application

• Biochemical Research: Used as a potent and specific activator of Protein Kinase C (PKC) isoforms in signal transduction studies.
• Oncology Research: Serves as a critical tool compound for studying tumor promotion, cell proliferation, and apoptosis mechanisms.
• Dermatological Studies: Applied in research models investigating skin inflammation, hyperplasia, and tumorigenesis.
• Pharmacology & Toxicology: Employed to elucidate the structure-activity relationships (SAR) of phorbol esters and their cellular targets.
• Cell Biology: Utilized in assays to study neutrophil activation, cytokine production, and other immune responses.
• Standards & Reference Material: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	12-o-Undecadienoylphorbol-13-Acetate
CAS No.	85527-86-2
Molecular Formula	C36H52O8
Molecular Weight	612.80 g/mol
Synonyms	12-O-(2E,4E,6E,8E)-Undecatetraenoylphorbol 13-acetate; 12-O-Undeca-2,4,6,8-tetraenoylphorbol-13-acetate; PDBu analogue; Phorbol 12-(2,4,6,8-undecatetraenoate) 13-acetate; 12-O-(2E,4E,6E,8E-Undecatetraenoyl)phorbol-13-acetate; TPA congener; PKC activator derivative
EINECS	Contact for details

Quality Control

Every batch of 12-o-Undecadienoylphorbol-13-Acetate is manufactured and analyzed under strict quality management systems to ensure identity, purity, and consistency for research applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. For long-term storage, keep desiccated under an inert atmosphere. The compound is light-sensitive and should be handled in a controlled environment. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.