Description

3-Deoxyaphidicolin is a structurally simplified analog of the natural diterpenoid aphidicolin, a known inhibitor of DNA polymerase. This compound is of significant interest in biochemical and pharmacological research due to its potential as a more accessible tool for studying eukaryotic DNA replication and cell cycle progression. It serves as a critical intermediate and reference standard for researchers in pharmaceutical development, oncology research, and molecular biology, particularly for those investigating novel antiproliferative agents.

Application

• Biochemical Research: Used as a specific inhibitor in studies of eukaryotic DNA polymerases alpha, delta, and epsilon to elucidate DNA replication mechanisms.
• Anticancer Agent Development: Serves as a lead compound and synthetic intermediate for developing novel chemotherapeutic agents targeting rapidly dividing cells.
• Cell Cycle Studies: Employed in laboratory settings to induce cell cycle arrest, typically at the G1/S phase boundary, for functional genomics and cytology research.
• Antiviral Research: Investigated for potential activity against DNA viruses (e.g., herpesviruses, poxviruses) that rely on host cell polymerases for replication.
• Reference Standard: Utilized as a high-purity analytical standard in quality control and method development for pharmaceutical R&D laboratories.
• Enzyme Inhibition Profiling: A key tool for screening and characterizing the selectivity of new polymerase inhibitors in drug discovery pipelines.

Basic Information

Product Name	3-Deoxyaphidicolin
CAS No.	85483-00-7
Molecular Formula	C20H32O3
Molecular Weight	320.47 g/mol
Synonyms	(+)-3-Deoxyaphidicolin; Aphidicolin, 3-deoxy-; 3-Deoxyaphidicolane-7,18-diol; NSC 339586; 7,18-Aphidicolanediol, 3-deoxy-; 3-Desoxyaphidicolin
EINECS	Contact for details

Quality Control

Our 3-Deoxyaphidicolin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ISO 9001 guidelines, and our analytical methods, including HPLC and NMR, are validated to provide reliable data for critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.