Description

S- (+)-Rolipram is the pharmacologically active enantiomer of the selective phosphodiesterase 4 (PDE4) inhibitor Rolipram. This high-purity chiral compound is a critical research tool for studying cAMP-mediated signaling pathways and their role in inflammation, depression, and memory. It is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on neurobiology and immunology. Our supply ensures consistent quality and reliable availability for your most demanding projects.

Application

• Biomedical Research: A standard tool compound for investigating the physiological and pathological roles of PDE4 enzymes in cellular and animal models.
• Neuropharmacology Studies: Used to explore potential therapeutic applications for neurological disorders, including depression, cognitive impairment, and neurodegenerative diseases.
• Immunology & Inflammation Research: Employed to study the modulation of inflammatory cytokine production and the potential for treating autoimmune and inflammatory conditions.
• Pharmaceutical Development: Serves as a reference standard and a starting point for the development of novel, more selective PDE4 inhibitors.
• Academic & Institutional Labs: Fundamental reagent for graduate and post-doctoral research in signal transduction and molecular pharmacology.
• Biochemical Assay Development: Used as a control and calibrant in high-throughput screening (HTS) assays targeting PDE4 activity.

Basic Information

Product Name	S- (+)-Rolipram
CAS No.	85416-73-5
Molecular Formula	C16H21NO3
Molecular Weight	275.34 g/mol
Synonyms	(S)-Rolipram; (-)-Rolipram; (S)-(-)-Rolipram; 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinone, (S)-; PDE4 Inhibitor (S)-enantiomer; (3S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one; ZK 62711 (S-enantiomer)
EINECS	Contact for details

Quality Control

Our S- (+)-Rolipram is manufactured under strict quality management systems. Every batch is subjected to comprehensive analytical testing, including chiral HPLC to confirm enantiomeric purity and identity verification. We provide full traceability and Certificates of Analysis (COA) detailing purity, impurities, and analytical methods. Our quality commitment ensures the material meets the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.