Description

Saframycin R CAS NO 85411-35-4 is a potent member of the saframycin family of quinone-containing antibiotics, characterized by its complex pentacyclic structure. This compound is valued for its significant biological activity, particularly as a DNA-binding agent and topoisomerase inhibitor, making it a crucial intermediate and reference standard in pharmaceutical research and development. It is primarily sought by research institutions, biotechnology firms, and pharmaceutical companies engaged in the discovery and synthesis of novel anti-cancer and antimicrobial agents.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and pharmacologically active scaffold in the discovery of new anticancer therapeutics.
• Antitumor Agent Studies: Used in biochemical and cellular assays to investigate mechanisms of action involving DNA intercalation and topoisomerase inhibition.
• Antimicrobial Research: Employed as a model compound in studies targeting drug-resistant bacterial strains due to its potent antibiotic properties.
• Chemical Synthesis Intermediate: Acts as a sophisticated building block for the semi-synthesis of novel saframycin analogs and related natural products.
• Biochemical Tool Compound: Utilized in laboratory settings to study apoptosis induction and cellular signaling pathways in various cancer cell lines.

Basic Information

Product Name	Saframycin R
CAS No.	85411-35-4
Molecular Formula	C29H31N3O7
Molecular Weight	533.57 g/mol
Synonyms	Saframycin R; Antibiotic C-15003P3; NSC 339641; (1S,12S,13S,14S,26S,27S,28S)-12,13,14,26,27,28-Hexahydro-1,12:14,26-diepoxy-13,27-dimethoxy-6,10,21,25-tetramethyl-2H,23H-1,13:14,26-dimethenodibenzo[cd,lm][1,6,9,12,15]oxatetraazacyclooctadecine-2,4,7,9,16,18,21,23(3H,8H)-octone
EINECS	Contact for details

Quality Control

Our Saframycin R is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and pharmaceutical intermediates. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.