Description

2-Chloro-3-Fluoropyridine n-Oxide is a versatile halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its unique reactivity profile, enabling the construction of complex molecular architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing fluorinated heterocycles.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine substituents enhance biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of novel organic electronic materials, liquid crystals, and functional polymers.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Aromatic Substitution: The activated pyridine N-oxide ring facilitates selective substitution reactions for further functionalization.

Basic Information

Product Name	2-Chloro-3-Fluoropyridine n-Oxide
CAS No.	85386-94-3
Molecular Formula	C5H3ClFNO
Molecular Weight	147.54 g/mol
Synonyms	2-Chloro-3-fluoropyridine 1-oxide; 3-Fluoro-2-chloropyridine N-oxide; 2-Chloro-3-fluoropyridine N-oxide; Pyridine, 2-chloro-3-fluoro-, 1-oxide; 85386-94-3; 2-Chloro-3-fluoro-1-oxidopyridin-1-ium
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Fluoropyridine n-Oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.