Description

15-Deoxy-δ12,14-Prostaglandin D2 is a specialized prostaglandin analog and a potent bioactive lipid mediator. This compound is valued for its role as a high-affinity ligand for the chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) receptor, making it a critical tool in immunological and inflammatory research. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions focused on developing novel therapeutics for allergic and inflammatory diseases.

Application

• Pharmacological Research: Used as a reference standard and agonist in studies targeting the CRTH2 (DP2) receptor pathway.
• Drug Discovery & Development: Serves as a key biochemical tool for screening and validating potential anti-inflammatory drug candidates.
• Inflammation & Immunology Studies: Employed in in vitro and in vivo models to investigate mechanisms of asthma, allergic rhinitis, and other Th2-cell mediated conditions.
• Biochemical Assay Development: Acts as a critical component in developing and calibrating receptor binding and functional cellular assays.
• Academic Research: Supports fundamental research in eicosanoid biology, lipid signaling, and immune cell chemotaxis.
• Reference Standard: Provides a high-purity compound for analytical method development, qualification, and quality control in regulatory submissions.

Basic Information

Product Name	15-Deoxy-δ12,14-Prostaglandin D2
CAS No.	85235-11-6
Molecular Formula	C20H30O4
Molecular Weight	334.45 g/mol
Synonyms	15-Deoxy-δ12,14-PGD2; 15d-PGD2; 15-Deoxy-δ-12,14-prostaglandin D2; PGJ2 series metabolite; CRTH2 agonist; 9,15-Dioxoprosta-5,10,13-trien-1-oic acid; δ12-PGJ2; 15-Deoxy-δ12,14-PGJ2
EINECS	Contact for details

Quality Control

Every batch of 15-Deoxy-δ12,14-Prostaglandin D2 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data including HPLC purity, identity confirmation (IR, NMR), and specific optical rotation. A Certificate of Analysis (COA) detailing batch-specific results is supplied with each shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, solutions should be prepared in anhydrous solvents and kept at -80°C. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	Provided on COA
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.