Description

3,5-Dibromo-2-Fluorotoluene is a halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the strategic positioning of bromine and fluorine atoms on the toluene backbone, enabling selective functionalization and serving as a key precursor for complex molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the dibromo-fluorotoluene moiety imparts specific biological activity.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination due to the reactive bromine atoms.
• Fluorine Chemistry Research: Essential for studying structure-activity relationships (SAR) in medicinal chemistry by introducing fluorine and bromine substituents.
• Dye and Pigment Intermediate: Used in the manufacture of complex halogenated dyes and organic pigments.

Basic Information

Product Name	3,5-Dibromo-2-Fluorotoluene
CAS No.	85233-13-2
Molecular Formula	C7H5Br2F
Molecular Weight	267.92 g/mol
Synonyms	2-Fluoro-3,5-dibromotoluene; 1,3-Dibromo-5-fluoro-2-methylbenzene; Toluene, 3,5-dibromo-2-fluoro-; 3,5-Dibromo-2-fluoro-1-methylbenzene; 2-Methyl-3,5-dibromofluorobenzene
EINECS	Contact for details

Quality Control

Our 3,5-Dibromo-2-Fluorotoluene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request for quality assurance and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	45 - 50 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.