Description

2,6-Difluorobenzyl Bromide is a versatile and high-value fluorinated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its dual functionality, where the benzyl bromide moiety acts as a potent alkylating agent and the fluorine atoms impart unique electronic and steric properties to the final molecule. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries who require precise molecular modifications to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) for central nervous system (CNS) drugs, kinase inhibitors, and anti-cancer agents.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated aromatic cores for electronic display materials, improving charge transport and thermal stability.
• Polymer & Resin Modification: Employed to introduce fluorinated benzyl groups into polymer chains, altering surface properties, chemical resistance, and durability of specialty polymers.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create biaryl structures common in medicinal chemistry.
• Ligand & Catalyst Development: Utilized for synthesizing novel fluorinated ligands for metal catalysts, fine-tuning their reactivity and selectivity in asymmetric synthesis.

Basic Information

Product Name	2,6-Difluorobenzyl Bromide
CAS No.	85118-00-9
Molecular Formula	C7H5BrF2
Molecular Weight	207.02 g/mol
Synonyms	1-(Bromomethyl)-2,6-difluorobenzene; (2,6-Difluorophenyl)methyl Bromide; α-Bromo-2,6-difluorotoluene; 2,6-Difluoro-α-bromotoluene; 2,6-Difluorobenzylbromide; 2,6-Difluorobenzyl Bromide; Bromo(2,6-difluorophenyl)methane
EINECS	Contact for details

Quality Control

Our 2,6-Difluorobenzyl Bromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistent performance. We provide detailed Certificates of Analysis (COA) with every shipment, documenting identity, assay, and impurity profiles. Our quality commitment aligns with cGMP and ISO 9001 standards to meet the rigorous demands of pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent hydrolysis. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.