Description

2,5-Difluorobenzyl Bromide is a versatile and highly reactive benzyl bromide derivative, distinguished by its two fluorine substituents. This compound is a critical building block in advanced organic synthesis, enabling the efficient introduction of the difluorobenzyl moiety into target molecules. It is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluorobenzyl group can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalysis and molecular recognition studies.
• Material Science Research: Employed in the synthesis of functionalized monomers and advanced organic materials, such as liquid crystals and polymers.
• Fluorinated Compound Library: Essential for medicinal chemistry teams building diverse compound libraries to explore structure-activity relationships (SAR).
• Cross-Coupling Reactions: Acts as an effective electrophile in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form complex biaryl structures.

Basic Information

Product Name	2,5-Difluorobenzyl Bromide
CAS No.	85117-99-3
Molecular Formula	C7H5BrF2
Molecular Weight	207.02 g/mol
Synonyms	α-Bromo-2,5-difluorotoluene; 1-(Bromomethyl)-2,5-difluorobenzene; (2,5-Difluorophenyl)methyl Bromide; 2,5-Difluoro-α-bromotoluene; 2,5-Difluorobenzylbromide; 2,5-DFBB
EINECS	Contact for details

Quality Control

Our 2,5-Difluorobenzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its moisture-sensitive (hygroscopic) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.