Description

15(R)-Iloprost is a potent, stereochemically defined analog of prostacyclin (PGI2) with significant biological activity. This high-purity compound is critical for advanced pharmaceutical research and development, particularly in the study of vascular and pulmonary systems. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focusing on cardiovascular therapeutics, pulmonary arterial hypertension (PAH), and related inflammatory pathways. The product is supplied under stringent quality controls to ensure reliability for sensitive applications.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quality control and analytical method development of iloprost-based drug products.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the synthesis and scale-up production of therapeutic formulations targeting pulmonary arterial hypertension (PAH).
• Biomedical Research: A key tool for in vitro and in vivo studies investigating vasodilation, platelet aggregation inhibition, and cytoprotective mechanisms.
• Cell Culture & Signaling Studies: Employed to study the role of the IP receptor and downstream cAMP pathways in vascular endothelial and smooth muscle cells.
• Drug Discovery & Development: Utilized in high-throughput screening (HTS) and structure-activity relationship (SAR) studies for novel prostaglandin analogs.

Basic Information

Product Name	15(R)-Iloprost
CAS No.	85026-51-3
Molecular Formula	C₂₂H₃₂O₄
Molecular Weight	360.49 g/mol
Synonyms	15(R)-Iloprost; (5Z)-5-[(3aR,4R,5R,6aS)-5-Hydroxy-4-((E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl)hexahydro-2H-cyclopenta[b]furan-2-ylidene]pentanoic Acid; ZK 36374 (15R-isomer); Iloprost (15R-epimer); 15-epi-Iloprost; Prostacyclin PGI2 Analog
EINECS	Contact for details

Quality Control

Our 15(R)-Iloprost is manufactured and tested under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling, to ensure it meets the high standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers should be sealed under vacuum or nitrogen after each use and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.