Description

17A-Ethynylestradiol 17B-(A-Glucuronide)Potassium is a high-purity, conjugated metabolite reference standard of the synthetic estrogen ethinylestradiol. This compound is critical for analytical and research applications requiring precise quantification and identification of steroid hormone metabolites. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and environmental testing facilities for method development, validation, and quality control.

Application

• Pharmaceutical Reference Standard: For the quantitative analysis and quality control of ethinylestradiol and its metabolites in active pharmaceutical ingredients (APIs) and finished drug products.
• Clinical Research & Toxicology: Used as a calibrant and internal standard in LC-MS/MS and HPLC assays to study drug metabolism, pharmacokinetics, and bioequivalence in human plasma and urine.
• Environmental Monitoring: Serves as a key analytical standard for detecting and quantifying trace levels of synthetic estrogen residues and their glucuronidated conjugates in water and wastewater.
• Biochemical Research: Employed in studies investigating steroid hormone conjugation pathways, enzyme activity (e.g., UDP-glucuronosyltransferases), and receptor binding assays.
• Forensic Analysis: Utilized in confirmatory testing for the presence of performance-enhancing drugs or controlled substances in biological samples.
• Diagnostic Kit Manufacturing: Acts as a critical raw material in the production of immunoassay kits and other in-vitro diagnostic (IVD) devices for hormone level testing.

Basic Information

Product Name	17A-Ethynylestradiol 17B-(A-Glucuronide)Potassium
CAS No.	84955-93-1
Molecular Formula	C26H33KO8
Molecular Weight	512.64 g/mol
Synonyms	Ethinyl Estradiol Glucuronide Potassium Salt; 17α-Ethynylestradiol 17β-D-Glucuronide Potassium Salt; EE2-17Glu K+; Potassium (17α)-17-ethynyl-3,17-dihydroxyestra-1,3,5(10)-trien-17β-yl β-D-glucopyranosiduronate; 17α-Ethynyl-1,3,5(10)-estratriene-3,17β-diol 17β-D-Glucuronide Potassium Salt; Ethinylestradiol Glucuronide K Salt; NSC 113927
EINECS	Contact for details

Quality Control

Every batch of 17A-Ethynylestradiol 17B-(A-Glucuronide)Potassium is manufactured and analyzed under strict quality management systems. Our products undergo rigorous identity, purity, and potency testing to ensure compliance with the high standards required for reference materials and pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA), detailing results for assay, related substances, residual solvents, and specific identity tests (e.g., HPLC, NMR, MS), is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR/MS)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.