Description

Pyridine, 4-(Difluoromethyl)-2-Fluoro- (9Ci) is a specialized fluorinated pyridine derivative, a high-value building block in advanced organic synthesis. Its unique difluoromethyl and fluoro substituents make it a critical intermediate for introducing fluorine atoms into target molecules, a key strategy in modern pharmaceutical and agrochemical design. This compound is essential for R&D and production chemists in the life sciences sector seeking to enhance the metabolic stability, bioavailability, and binding affinity of novel compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and manufacture of advanced herbicides, fungicides, and insecticides where fluorine incorporation improves efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials for displays and lighting.
• Fluorinated Ligand & Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis, leveraging fluorine's electronic effects.
• Advanced Polymer Modification: Used to introduce fluorine functionality into polymer backbones, enhancing material properties like chemical resistance and thermal stability.
• Positron Emission Tomography (PET) Tracer Precursor: Potential use in synthesizing fluorine-18 labeled compounds for medical imaging.

Basic Information

Product Name	Pyridine, 4-(Difluoromethyl)-2-Fluoro- (9Ci)
CAS No.	84940-51-2
Molecular Formula	C7H6F3N
Molecular Weight	161.12 g/mol
Synonyms	2-Fluoro-4-(difluoromethyl)pyridine; 4-(Difluoromethyl)-2-fluoropyridine; 2-Fluoro-4-difluoromethylpyridine; Pyridine, 4-(difluoromethyl)-2-fluoro-; 84940-51-2; 4-Difluoromethyl-2-fluoropyridine; 2-Fluoro-4-(difluoromethyl)pyridine (9CI)
EINECS	Contact for details

Quality Control

Our Pyridine, 4-(Difluoromethyl)-2-Fluoro- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet your specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.