Description

o-Desmethyldiltiazem CAS NO 84903-78-6 is a key pharmaceutical intermediate and metabolite of the calcium channel blocker Diltiazem. This compound is of significant importance for research and development in cardiovascular pharmacology and for the synthesis of related active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical manufacturers, analytical laboratories, and research institutions focused on drug metabolism studies, impurity profiling, and the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of Diltiazem and its structural analogs.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Metabolite Studies: Essential for in-vitro and in-vivo pharmacokinetic and pharmacodynamic research to understand drug metabolism pathways.
• Impurity Profiling: Serves as a known impurity standard to ensure the purity and safety of Diltiazem API batches according to ICH guidelines.
• Research Chemical: Utilized in academic and industrial research to investigate structure-activity relationships (SAR) within the benzothiazepine class of drugs.

Basic Information

Product Name	o-Desmethyldiltiazem
CAS No.	84903-78-6
Molecular Formula	C21H26N2O4S
Molecular Weight	402.51 g/mol
Synonyms	Desmethyldiltiazem; Diltiazem Impurity C; Diltiazem Metabolite I; (2S,3S)-5-[2-(Dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-4-methyl-3-(phenylcarbamoyl)-1,5-benzothiazepin-4-ol 1,1-Dioxide; 3-Desmethyldiltiazem; o-Desmethyl Diltiazem; Diltiazem Related Compound C
EINECS	Contact for details

Quality Control

Our o-Desmethyldiltiazem is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.