Description

[(1R)-2-(4-Hydroxyphenyl)-1-[[(1S)-1-[[(2S)-3-Methyl-2-Methylamino-But Anoyl]Carbamoyl]-2-Phenyl-Ethyl]Amino]Ethyl]Phosphonic Acid is a sophisticated, non-proteinogenic amino acid derivative featuring a phosphonic acid group, which is of significant interest in advanced pharmaceutical research and development. This compound's complex chiral structure makes it a valuable building block for designing novel bioactive molecules, particularly in the field of enzyme inhibition and peptide mimetics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical synthesis specialists seeking high-purity, structurally defined intermediates for drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of investigational new drugs, particularly those targeting metabolic or enzymatic pathways.
• Protease Inhibitor Research: Used in the development of peptide-based or peptidomimetic inhibitors due to its phosphonic acid moiety, which can mimic transition states in enzymatic reactions.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes to study protein function and enzyme mechanisms in biological systems.
• Advanced Peptide Synthesis: Acts as a specialized amino acid analog for incorporating unique structural and functional properties into synthetic peptides.
• Medicinal Chemistry: Provides a template for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	[(1R)-2-(4-Hydroxyphenyl)-1-[[(1S)-1-[[(2S)-3-Methyl-2-Methylamino-But Anoyl]Carbamoyl]-2-Phenyl-Ethyl]Amino]Ethyl]Phosphonic Acid
CAS No.	84890-90-4
Molecular Formula	C24H32N3O6P
Molecular Weight	489.50 g/mol
Synonyms	(2R)-2-Amino-3-(4-hydroxyphenyl)-1-[[(1S)-1-[[(2S)-3-methyl-2-(methylamino)butanoyl]amino]-2-phenylethyl]amino]ethylphosphonic acid; N-[(1S)-1-[[(2S)-3-Methyl-2-(methylamino)butanoyl]amino]-2-phenylethyl]-L-tyrosylphosphonic acid amide; Phosphonic acid, P-[2-amino-2-(4-hydroxyphenyl)ethyl]-, N-[(1S)-1-[[(2S)-3-methyl-2-(methylamino)-1-oxobutyl]amino]-1-oxo-2-phenylethyl]-, (R)-; A complex phosphonotyrosine derivative
EINECS	Contact for details

Quality Control

Our production of [(1R)-2-(4-Hydroxyphenyl)-1-[[(1S)-1-[[(2S)-3-Methyl-2-Methylamino-But Anoyl]Carbamoyl]-2-Phenyl-Ethyl]Amino]Ethyl]Phosphonic Acid adheres to stringent quality protocols suitable for research and development applications. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, chiral purity, and chemical integrity. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data upon request, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.